Title: A Prospective, Randomized, Blinded Assessment of Multitarget Thalamic and Pallidal Deep Brain Stimulation in a case of Hemidystonia Author:
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The effect of unilateral thalamic deep brain stimulation on the vocal dysfunction in a patient with spasmodic dysphonia: interrogating cerebellar and pallidal neural circuits.
Spasmodic dysphonia (SD) is a neurological disorder of the voice where a patient's ability to speak is compromised due to involuntary contractions of the intrinsic laryngeal muscles. Since the 1980s, SD has been treated with botulinum toxin A (BTX) injections into the throat. This therapy is limited by the delayed-onset of benefits, wearing-off effects, and repeated injections required every 3 ...
متن کاملPallidaldeep brain stimulation for the treatment of DYT6 dystonia: a case report and review of literature
Little is known about the results of pallidal deep brain stimulation (DBS) in DYT6 dystonia. This will be the first report of DYT6 dystonia treated with pallidal DBS from Iran. A 21 years old male patient with DYT6 dystonia underwent bilateral deep brain stimulation. The target of DBS was the sensorimotor region of the posteroventralglobuspallidusinternus (GPi). DBS parameters included an amp...
متن کاملBilateral pallidal stimulation in cervical dystonia: blinded evidence of benefit beyond 5 years.
The local injection of botulinum toxin is accepted as the first-line treatment of primary cervical dystonia. This approach provides adequate symptomatic relief for most patients, but up to one-third will have an unsatisfactory response. Deep brain stimulation of the globus pallidus internus has been increasingly used in dystonic syndromes that are refractory to best pharmacological approaches. ...
متن کاملBoth thalamic and pallidal deep brain stimulation for myoclonic dystonia.
Myoclonic dystonia is poorly managed with medication and may be severe enough to warrant surgical intervention. Surgery has targeted either the globus pallidus pars interna (GPi) or the thalamus, but there is no accepted target for this condition. The authors present the case of a 23-year-old man treated with unilateral deep brain stimulation in both the thalamus and GPi. His movement disorder ...
متن کاملA Prospective Pilot Trial for Pallidal Deep Brain Stimulation in Huntington’s Disease
BACKGROUND Movement disorders in Huntington's disease are often medically refractive. The aim of the trial was assessment of procedure safety of deep brain stimulation, equality of internal- and external-pallidal stimulation and efficacy followed-up for 6 months in a prospective pilot trial. METHODS In a controlled double-blind phase six patients (four chorea-dominant, two Westphal-variant) w...
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تاریخ انتشار 2015